People who have migrated from the planes to an area adjoining Rohtang pass about six months back have more RBCs and their haemoglobin has a lower binding affinity to O2.
At higher altitudes, hemoglobin binds less tightly to oxygen. So, when people move from lower areas to a location near Rohtang Pass (above 10,000 meters) for around six months, their bodies respond by producing more RBCs. This increase helps counterbalance the reduced binding capacity of hemoglobin to oxygen at such elevations.